Browse recruiting and upcoming clinical trials for familial Mediterranean fever.
Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026
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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.
Who can join AIAdults (18+) with an immune-mediated inflammatory disease such as lupus, multiple sclerosis, psoriatic arthritis, severe asthma, atopic dermatitis, angioedema, systemic sclerosis, or Behçet disease.
What is being studied AICollects clinical data, yearly disease measures, quality-of-life surveys, and blood samples for biomarker and genetic research.
Who can join AIChildren or people with Familial Mediterranean Fever or Still's disease (SJIA or AOSD) who received canakinumab ≥6 months and have ≥3 years of follow-up data.
What is being studied AICollects real-world data on treatment patterns and outcomes after canakinumab in FMF and Still's disease.
Who can join AIPeople with suspected or known inflammatory cardiovascular involvement from a range of conditions — for example myocarditis, pericarditis, sarcoidosis, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, Takayasu arteritis, and others.
What is being studied AICollects imaging and clinical data from CMR, cardiac PET, and echocardiography to detect heart involvement.
Who can join AIPeople with systemic autoimmune or autoinflammatory diseases (for example Behcet disease; ANCA-positive vasculitis; Takayasu or giant cell arteritis; Sjögren's; rheumatoid arthritis; celiac disease).
What is being studied AICollects clinical data, disease activity scores, and blood and stool samples for a biobank.
Who can join AIPeople with NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4‑MAS, Still's or other undifferentiated autoinflammatory diseases; unaffected relatives and healthy people.
What is being studied AICollects clinical data and blood/tissue samples for genetic, immune, and biomarker studies of disease course.
Who can join AIPeople with familial Mediterranean fever or other autoinflammatory/periodic fever disorders, their family members, and healthy volunteers.
What is being studied AICollects genetic samples and clinical data to study genes and immune features in autoinflammatory diseases.
Who can join AIPeople with inflammatory cardiovascular diseases and autoimmune rheumatic diseases (e.g., myocarditis, pericarditis, lupus, rheumatoid arthritis).
What is being studied AICollect blood samples to build a biobank and perform immunophenotyping and proteomic analyses.
Who can join AIAdults with autoinflammatory diseases (including FMF, TRAPS, MKD, Cryopyrin Associated Periodic Syndrome, Haploinsufficiency) and matched control groups.
What is being studied AICollects clinical signs, blood/urine biomarkers, and biopsies to study mast cell involvement.
Who can join AIPeople aged 6 months–80 years with a diagnosis of Familial Mediterranean Fever (study also assesses non‑celiac gluten/wheat sensitivity).
What is being studied AICollects patient reports on whether wheat or other foods trigger FMF attacks and self-reported gluten/wheat sensitivity.
Who can join AIAdults with rheumatic autoimmune diseases (for example rheumatoid arthritis, lupus, scleroderma, ankylosing spondylitis) and healthy adult volunteers.
What is being studied AICollects clinical data and biospecimens (blood, saliva, urine, stool, tissue) for research.
Who can join AIChildren and adolescents aged 6–18 with Juvenile Idiopathic Arthritis (JIA) or Familial Mediterranean Fever (FMF), and healthy children 6–18 as controls.
What is being studied AIMeasures gait patterns in children with JIA or FMF using a Digitsole Pro® smart insole.
Trials that may include familial Mediterranean fever (28)
ClinicalTrials.gov returned these when we searched for this condition, but we could not confirm from the registry records that they are intended for people with it. Check each trial’s eligibility criteria, and ask the study team if you are unsure.
Who can join AIPeople with multiple refractory autoimmune diseases, including Systemic Lupus Erythematosus, Systemic Sclerosis, Sjögren syndrome, and others.
What is being studied AITests BCMA‑CD19 CAR‑T cell therapy for multiple refractory autoimmune diseases.
Who can join AIPeople with antiphospholipid syndrome, bullous pemphigoid, Behçet's syndrome, dermatomyositis, immune‑mediated necrotizing myopathy, or immune thrombocytopenia.
What is being studied AITests multiple doses of RAY121 (classical complement pathway inhibitor) for safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy.
Who can join AIChildren with Behçet's disease (oral ulcers, age 2 and older) or juvenile psoriatic arthritis (age 5 to <18) who completed Week 52 of an apremilast core study.
What is being studied AITests long-term safety of apremilast in children with oral ulcers from Behçet's or JPsA.
Who can join AIAdults aged 18–50 with Behçet's disease (diagnosed using International Study Group criteria) who had lower-extremity venous thrombosis confirmed within the past 14 days. The registry also requires either no previous vascular involvement or no previous immunosuppressive treatment for vascular involvement.
What is being studied AICompares immunosuppression alone versus immunosuppression plus rivaroxaban for Behçet-related leg clots.
Who can join AIAdults with CAPS (Muckle-Wells syndrome or NOMID) who developed anakinra-induced amyloidosis and are enrolled on NIH protocol 17‑I‑0016.
What is being studied AIUses 124I-AT-01 PET/CT scans to detect and measure organ-specific amyloid in people with anakinra-induced amyloidosis.
Who can join AIPeople aged 6 years and older with genetically confirmed CAPS (familial cold urticaria, Muckle‑Wells, CINCA) and healthy household controls.
What is being studied AIMeasures circadian rhythms, melatonin timing/levels, activity, and inflammatory clock-related biomarkers in CAPS and household controls.
Who can join AIPeople aged 1 month–99 years with PFAPA or other tonsil disorders (for example tonsillitis, obstructive sleep apnea, or sleep-disordered breathing).
What is being studied AICollects blood, tissue, and other samples to study genetics, immune features, and microbiota in tonsil disorders.
Who can join AIPregnant women with vasculitis, including Behçet's disease, granulomatosis with polyangiitis, Takayasu arteritis, polyarteritis nodosa, and others.
What is being studied AICollects online questionnaires about vasculitis severity, pregnancy experiences, and pregnancy outcomes.