Tuberous Sclerosis Complex

Browse recruiting and upcoming clinical trials for tuberous sclerosis complex.

Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026

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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.

27 trials + 3 related

Showing 27 trials, plus 3 related

Who can join AIAdults with certain advanced mTOR‑sensitive solid tumors: HR+/HER2‑ breast cancer, RCC, NETs, TSC‑associated tumors, or HCC.
What is being studied AITests safety, tolerability, and pharmacokinetics of weekly IV Sapu003 (with or without exemestane).
Study typeTreatment (drug) · Phase 1
CountriesAustralia
Who can join AIPeople with Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC), or Hemimegalencephaly (HME).
What is being studied AITests safety, tolerability, and pharmacokinetics of oral SVG103 (paxalisib) in people with FCD-II, TSC, or HME.
Study typeTreatment (drug) · Phase 1/2
CountriesAustralia
Who can join AIPeople with neurodevelopmental disorders and anxiety, including autism, fragile X, tuberous sclerosis, 22q11 deletion, ADHD, and tic/Tourette disorders.
What is being studied AICompares sertraline with placebo for anxiety symptoms in children and adolescents with neurodevelopmental disorders.
Study typeTreatment (drug) · Phase 2
CountriesCanada
Enrolling by invitation
Who can join AIAdult caregivers of a person with tuberous sclerosis complex (TSC).
What is being studied AITests an online 3-session ACT-based caregiver well-being program (Well-Beans for Caregivers).
Study typeTreatment (other)
CountriesAustralia, United States
Enrolling by invitation
Who can join AIInfants (15 months or younger) with a confirmed diagnosis of one of several rare neurogenetic conditions and their parent/primary caregiver (English-speaking household).
What is being studied AITests a parent-focused early intervention (PIXI) for infants diagnosed with rare neurogenetic disorders.
Study typeTreatment (other)
CountriesUnited States
Who can join AIChildren aged 8–17 with a clinical or genetic diagnosis of tuberous sclerosis complex (TSC) who have behavioral/emotion dysregulation.
What is being studied AITests a remote group behavioral program for emotion dysregulation in TSC.
Study typeDiagnostic
CountriesUnited States
Who can join AIPeople aged 16–30 with chronic kidney disease or related kidney conditions (proteinuria; blood pressure control; CAKUT; nephrotic syndrome; sickle‑cell nephropathy; tuberous sclerosis; cancer survivors).
What is being studied AITests whether a smartphone app improves adherence to KDIGO 2024 CKD guideline recommendations.
Study typeOther
CountriesIreland
Who can join AIAdults with Alport syndrome, Fabry disease, tuberous sclerosis complex, SLE with kidney involvement, non-rare CKD, or people without CKD as controls.
What is being studied AICompares periodontal health in rare kidney diseases, CKD controls, and population controls.
Study typeObservational
CountriesRomania
Who can join AIAdults (≥18) with a new or previous clinical diagnosis of any listed neuroendocrine neoplasm or related endocrine tumor or syndrome (e.g., pancreatic/GI NEN, medullary thyroid cancer, paraganglioma/pheochromocytoma, pituitary tumor, MEN syndromes).
What is being studied AICollects genetic and clinical data to find inherited and tumor-specific DNA changes.
Study typeObservational
CountriesMexico
Who can join AIAdults (18+) with complex rare genetic syndromes listed in the study, e.g., Prader‑Willi, Turner, Noonan, Rett and others.
What is being studied AICollects and analyzes adult medical records to describe health problems, labs, symptoms, and medication use.
Study typeObservational
CountriesNetherlands
Who can join AIPeople with familial or early‑onset cancers (including many hereditary cancer syndromes) and their biological relatives.
What is being studied AICollects family histories and blood/tumor samples for genetic sequencing to find cancer-predisposing genes.
Study typeObservational
CountriesUnited States
Who can join AIPeople with cystic fibrosis, pulmonary fibrosis, tuberous sclerosis, asthma, pulmonary sarcoidosis, other lung diseases, and healthy volunteers.
What is being studied AISurveys genetic variants and gene expression in people with and without lung disease.
Study typeObservational
CountriesUnited States
Who can join AIPeople with lymphangioleiomyomatosis and related lung conditions, including pneumothorax and tuberous sclerosis–associated lung disease.
What is being studied AICollects clinical data, imaging, and genetic and protein analyses to study LAM disease processes.
Study typeObservational
CountriesUnited States
Enrolling by invitation
Who can join AIPeople or couples with a molecularly confirmed inherited skin disease who considered or had prenatal diagnosis (PND) or preimplantation genetic testing (PGT).
What is being studied AICollects past clinical and reproductive data on prenatal diagnosis and preimplantation genetic testing outcomes.
Study typeObservational
CountriesNetherlands
Who can join AIChildren and people with one of the many rare kidney diseases listed in this registry.
What is being studied AICollects clinical data, patient-reported outcomes, and samples to support research.
Study typeRegistry
CountriesUnited Kingdom
Who can join AIPeople of any age with tuberous sclerosis complex (TSC) or with sporadic lymphangioleiomyomatosis (LAM).
What is being studied AICollects and stores biosamples and linked clinical data from people with TSC or sporadic LAM.
Study typeRegistry
CountriesCanada, United States

Trials that may include tuberous sclerosis complex (3)

ClinicalTrials.gov returned these when we searched for this condition, but we could not confirm from the registry records that they are intended for people with it. Check each trial’s eligibility criteria, and ask the study team if you are unsure.

Who can join AIAdults with multiple sclerosis who have problems with postural balance.
What is being studied AITests whether a progressive group balance program (HiBalance-MS) changes balance, walking, and motor-cognitive function.
Study typeTreatment (other)
CountriesSweden
Who can join AIAdults 18–55 with relapsing‑remitting multiple sclerosis (disease duration <15 years) who have acute inflammatory demyelinating brain lesions.
What is being studied AITests whether clemastine changes MRI measures of myelin in acute demyelinating brain lesions.
Study typeTreatment (drug) · Phase 1/2
CountriesUnited States