Thrombotic Thrombocytopenic Purpura

Browse recruiting and upcoming clinical trials for thrombotic thrombocytopenic purpura.

Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026

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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.

18 trials

Showing 18 trials

Who can join AIAdults 18–65 with multiple refractory autoimmune diseases such as SLE, Sjögren, systemic sclerosis, ANCA‑vasculitis, inflammatory myopathy, Behçet, IgG4‑RD, antiphospholipid syndrome, or TTP.
What is being studied AITests BCMA-CD19 CAR-T cell therapy for multiple refractory autoimmune diseases.
Study typeTreatment (drug) · Phase 2
CountriesChina
Who can join AIPeople with immune-mediated thrombotic thrombocytopenic purpura (iTTP), a form of thrombotic microangiopathy, who meet clinical/lab entry criteria.
What is being studied AITests a PEX-free regimen using plasma infusions, caplacizumab and immunosuppression for iTTP.
Study typeTreatment (procedure/device)
CountriesFrance, Martinique, Reunion
Who can join AIAdults (18+) having an acute thrombotic microangiopathy (TMA) episode, including immune‑mediated TTP.
What is being studied AITests safety, dosing, pharmacology, and clinical activity of TGD001 given by IV bolus.
Study typeTreatment (drug) · Phase 1/2
CountriesNot posted yet
Not yet recruiting
Who can join AIPeople with hereditary or acquired thrombotic thrombocytopenic purpura (TTP) in remission who have severe ADAMTS13 deficiency (<10%).
What is being studied AITests whether daily low‑dose aspirin versus placebo affects stroke, relapse, and major bleeding in TTP.
Study typeTreatment (drug) · Phase 2/3
CountriesNot posted yet
Who can join AIPeople aged 12 and older with immune-mediated (acquired) TTP and healthy Caucasian Italian volunteers without TTP.
What is being studied AIGenetic variants and A20 (TNFAIP3) expression in people with immune-mediated TTP and controls.
Study typeOther
CountriesItaly
Who can join AIAdults (≥18 years) with acquired (immune-mediated) thrombotic thrombocytopenic purpura (iTTP) who were treated with daratumumab.
What is being studied AICollects retrospective data on safety and ADAMTS13 response after daratumumab in iTTP.
Study typeObservational
CountriesItaly
Who can join AIPeople diagnosed with thrombotic thrombocytopenic purpura (TTP) with severe ADAMTS13 deficiency (activity <10%).
What is being studied AICollects clinical and follow-up data to build a TTP patient database.
Study typeObservational
CountriesChina
Who can join AIPeople of any age with congenital TTP (severe congenital ADAMTS13 deficiency) treated with rADAMTS13 via the Early Access Program.
What is being studied AICollects and reviews medical-record data before and after rADAMTS13 treatment.
Study typeObservational
CountriesNot posted yet
Who can join AIPeople diagnosed with thrombosis and hemostasis diseases (examples: ITP, TTP, hereditary or acquired hemophilia, DIC, thrombophilia, DVT, PE, and related disorders).
What is being studied AICollects medical records, questionnaires, and follow-up data on thrombosis and bleeding disorders.
Study typeRegistry
CountriesChina
Recruiting
Who can join AIPeople aged 12–99 hospitalized with an acute immune-mediated TTP episode (first event or relapse) and severe ADAMTS13 deficiency.
What is being studied AICollects clinical data and blood samples for ADAMTS13 and long-term outcome study.
Study typeRegistry
CountriesItaly