Splenic Marginal Zone Lymphoma

Browse recruiting and upcoming clinical trials for splenic marginal zone lymphoma.

Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026

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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.

11 trials + 1 related

Showing 11 trials, plus 1 related

Who can join AIPeople with relapsed or refractory B-cell non-Hodgkin lymphomas (including CLL/SLL, DLBCL, follicular, marginal-zone, and mantle cell lymphoma).
What is being studied AITests combining the drugs zanubrutinib and sonrotoclax for relapsed or refractory B‑cell NHL.
Study typeTreatment (drug) · Phase 1
CountriesUnited States
Who can join AIPeople with newly diagnosed, previously untreated marginal zone lymphoma, including extranodal (MALT), splenic, and nodal subtypes.
What is being studied AITests subcutaneous epcoritamab given on a step-up schedule for newly diagnosed marginal zone lymphoma.
Study typeTreatment (drug) · Phase 2
CountriesUnited States
Who can join AIPeople with relapsed or refractory B‑cell non-Hodgkin lymphoma, including DLBCL, follicular, mantle cell, marginal zone, and Waldenstrom macroglobulinemia.
What is being studied AITests a single IV infusion of SynKIR-310 (autologous T cells transduced with CD19 KIR‑CAR).
Study typeTreatment (drug) · Phase 1
CountriesUnited States
Who can join AIPeople with relapsed/refractory mature B‑cell malignancies (including various non‑Hodgkin lymphomas, CLL, and Waldenström).
What is being studied AITests safety, dosing, pharmacokinetics, and preliminary anti-tumor activity of oral SGR-1505.
Study typeTreatment (drug) · Phase 1
CountriesFrance, Italy, Moldova +5
Who can join AIPeople with indolent B‑cell non‑Hodgkin lymphomas such as mantle cell, follicular, splenic or nodal marginal zone, and extranodal (MALT) lymphoma.
What is being studied AITests safety, tolerability, and anti-tumor activity of kappa-targeted CAR T cells.
Study typeTreatment (drug) · Phase 1
CountriesUnited States
Who can join AIPeople with relapsed or refractory marginal zone lymphoma (nodal, splenic, or extranodal/MALT subtypes).
What is being studied AICompares mosunetuzumab alone versus mosunetuzumab plus zanubrutinib or polatuzumab vedotin for MZL.
Study typeTreatment (drug) · Phase 2
CountriesNot posted yet
Who can join AIOlder people with a confirmed or presumed cancer diagnosis, including leukemia, lymphoma, multiple myeloma, and other solid tumors.
What is being studied AICollects geriatric assessments and medical-record information for older patients with cancer.
Study typeObservational
CountriesUnited States
Who can join AIPeople being evaluated for a hematologic cancer or related blood or lymphoid disorder (leukemia, lymphoma, multiple myeloma, myelodysplastic and myeloproliferative disorders, and related neoplasms) at the University of North Carolina Hospitals — in the hematology/oncology clinics, the stem cell transplant clinic, or as an inpatient.
What is being studied AICollects and stores blood, tissue, and body-fluid samples for future laboratory research.
Study typeObservational
CountriesUnited States

Trials that may include splenic marginal zone lymphoma (1)

ClinicalTrials.gov returned these when we searched for this condition, but we could not confirm from the registry records that they are intended for people with it. Check each trial’s eligibility criteria, and ask the study team if you are unsure.

Who can join AIPeople with MBL, CLL/SLL, LPL/WM, or splenic marginal zone lymphoma (SMZL).
What is being studied AICollects blood, tissue and imaging and tracks clinical and molecular changes over time.
Study typeObservational
CountriesUnited States