Browse recruiting and upcoming clinical trials for Prader-Willi syndrome.
Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026
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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.
Who can join AIPeople aged 18–26 with Prader‑Willi syndrome, hypothalamic obesity, or general (non‑syndromic) obesity who have BMI in the obesity range.
What is being studied AITests weekly tirzepatide's effects on weight, body fat, appetite, and metabolic markers over 48 weeks.
Who can join AIAdults with intellectual disability (including autism spectrum disorder, Down syndrome, Fragile X, Williams, Prader‑Willi, and other related neurodevelopmental syndromes).
What is being studied AITests a 16-week inclusive exercise (PACE) program versus waitlist to increase physical activity and related outcomes.
Who can join AIAdults (≥18) with genetically confirmed Prader‑Willi syndrome and their caregivers.
What is being studied AIWhether daily auricular vagal stimulation affects emotion regulation, executive function, hyperphagia, depression, and quality of life.
Who can join AIPeople with Prader‑Willi syndrome aged 7 years and older who completed the End‑of‑Treatment visit in a qualifying parent pitolisant study.
What is being studied AITests long-term safety of pitolisant in people with Prader-Willi syndrome.
Who can join AIInfants (15 months or younger) with a confirmed diagnosis of one of several rare neurogenetic conditions and their parent/primary caregiver (English-speaking household).
What is being studied AITests a parent-focused early intervention (PIXI) for infants diagnosed with rare neurogenetic disorders.
ClinicalTrials.gov returned these when we searched for this condition, but we could not confirm from the registry records that they are intended for people with it. Check each trial’s eligibility criteria, and ask the study team if you are unsure.