Large Granular Lymphocytic Leukemia

Browse recruiting and upcoming clinical trials for large granular lymphocytic leukemia.

Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026

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ClinicalTrials.gov is the complete and most up-to-date source. Trials may be missing, and trial information may have changed since our last check. Always verify important information in the official registry.

14 trials + 2 related

Showing 14 trials, plus 2 related

Who can join AIAdults (18+) with T‑cell large granular lymphocytic leukemia (T‑LGLL) who need treatment, including untreated patients or those who have failed frontline therapy.
What is being studied AITests ruxolitinib to see if it induces responses and assesses safety in T-LGLL.
Study typeTreatment (drug) · Phase 2
CountriesUnited States
Who can join AIAdults with relapsed or refractory mature T‑cell or NK‑cell lymphomas (includes T-PLL, eligible even if untreated, and T‑LGL).
What is being studied AITests safety and dosing of ruxolitinib combined with duvelisib in T- and NK-cell lymphomas.
Study typeTreatment (drug) · Phase 1
CountriesUnited States
Who can join AIPeople diagnosed with certain hematological (blood) diseases or who received a bone marrow transplant at a participating hospital on or after January 1, 2020.
What is being studied AICollects clinical, treatment, outcome, and cost data for people with hematological diseases.
Study typeObservational
CountriesChina
Who can join AIOlder people with a confirmed or presumed cancer diagnosis, including leukemia, lymphoma, multiple myeloma, and other solid tumors.
What is being studied AICollects geriatric assessments and medical-record information for older patients with cancer.
Study typeObservational
CountriesUnited States
Who can join AIPeople being evaluated for a hematologic cancer or related blood or lymphoid disorder (leukemia, lymphoma, multiple myeloma, myelodysplastic and myeloproliferative disorders, and related neoplasms) at the University of North Carolina Hospitals — in the hematology/oncology clinics, the stem cell transplant clinic, or as an inpatient.
What is being studied AICollects and stores blood, tissue, and body-fluid samples for future laboratory research.
Study typeObservational
CountriesUnited States
Who can join AIPeople with pathologically confirmed mature T‑cell or NK‑cell lymphomas (many specific subtypes are included).
What is being studied AICollects clinical data and tumor specimens for a T-cell and NK-cell lymphoma research repository.
Study typeRegistry
CountriesUnited States
Who can join AIAdults (18+) with a confirmed diagnosis of CLL, SLL, HCL, Richter's transformation, B‑PLL, T‑PLL, T‑LGL or NK‑LGL leukemia.
What is being studied AICollects long-term clinical data and survival outcomes for people with listed lymphoid malignancies.
Study typeRegistry
CountriesGermany

Trials that may include large granular lymphocytic leukemia (2)

ClinicalTrials.gov returned these when we searched for this condition, but we could not confirm from the registry records that they are intended for people with it. Check each trial’s eligibility criteria, and ask the study team if you are unsure.

Who can join AIPeople with newly diagnosed Epstein‑Barr virus–positive T/NK‑cell lymphoproliferative diseases, including extranodal NK/T‑cell lymphoma, aggressive NK‑cell leukemia, systemic chronic active EBV (T/NK), and EBV‑positive nodal T/NK‑cell lymphoma.
What is being studied AICollects clinical data and blood/tissue samples to study outcomes and biomarkers in EBV-positive T/NK-cell diseases.
Study typeRegistry
CountriesChina