Browse recruiting and upcoming clinical trials for hereditary spastic paraplegia.
Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026
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Who can join AIChildren (4–17) with ankle equinus and one of: idiopathic toe walking, cerebral palsy, hereditary spastic paraparesis, TBI, SCI/tethering, stroke, or hereditary sensory‑motor neuropathy.
What is being studied AIWhether cutting the plantaris changes ankle dorsiflexion during equinus surgery.
Who can join AIChildren aged 4 months to 72 months with AP‑4–related hereditary spastic paraplegia; only children with molecularly confirmed SPG50 are eligible for the treatment arm, while the matched control group may include SPG47 or SPG52.
What is being studied AITests a single intrathecal dose of MELPIDA gene therapy versus matched untreated controls.
Who can join AIAdults with genetically confirmed SPAST (SPG4) hereditary spastic paraparesis who can walk for 6 minutes and already receive weekly physiotherapy.
What is being studied AITests whether a 6-week intensive physical rehabilitation program changes walking speed in SPG4 HSP.
Who can join AIAdults 18–70 who are first‑degree relatives of someone with SPG4 (SPAST), symptomatic people with a known SPAST mutation, or presymptomatic SPAST carriers.
What is being studied AITests clinical signs, imaging, and fluid biomarkers over time in people with or at risk for SPG4.
Who can join AIPeople aged 10–45 with genetically confirmed hereditary spastic paraplegia and isolated Achilles tendon contracture or equinovarus cavus foot deformity.
What is being studied AICollects prospective, long-term clinical outcomes after surgical correction of foot deformities in people with HSP.
Who can join AIPeople older than 4 and younger than 70 with hereditary spastic paraplegia (genetic or clinical diagnosis) who can walk indoors, with or without walking aids.
What is being studied AITests an intensive robot-assisted plus physical therapy rehabilitation program and collects gait and quality-of-life measures.
Who can join AIPeople with ataxia, hereditary spastic paraplegia, or spastic ataxia, plus presymptomatic mutation carriers, family members, and healthy community controls.
What is being studied AICollects long-term clinical data, biosamples, imaging, and patient-reported outcomes in SPAX diseases.
Who can join AIPeople of any age with a clinical and genetically confirmed diagnosis of hereditary spastic paraplegia type 4 (SPG4) or type 5A (SPG5A).
What is being studied AICollects clinical data, blood samples, and genetic information to build a shared registry and biobank.
Who can join AIPeople with hereditary spastic paraplegia or related disorders, their unaffected first/second‑degree adult relatives, and unrelated healthy controls.
What is being studied AICollects clinical data, biosamples, imaging, and genetic tests to study HSP progression and biomarkers.