Browse recruiting and upcoming clinical trials for Castleman disease.
Patient-friendly, AI-assisted summaries based on official ClinicalTrials.gov ↗ records. Last updated: Oct 10, 2026
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Who can join AIAdults (18–80) with idiopathic multicentric Castleman disease (iMCD) or Castleman's Disease who are refractory, relapsed, or intolerant to anti‑IL‑6 therapy.
What is being studied AITests ruxolitinib tablets as a treatment for previously treated idiopathic multicentric Castleman disease.
Who can join AIPeople with relapsed or refractory primary effusion lymphoma (PEL), plasmablastic lymphoma (PBL), or symptomatic KSHV‑associated multicentric Castleman disease (MCD).
What is being studied AITests subcutaneous daratumumab as a treatment for relapsed/refractory PEL, PBL, and KSHV‑MCD.
Who can join AIAdults with biopsy‑proven hyaline‑vascular unicentric Castleman disease with unresectable or partially resectable lesions, or who refuse surgery.
What is being studied AITests nintedanib as a drug treatment for unresectable or partially resectable unicentric Castleman disease.
Who can join AIPeople with HIV and unexplained lymphadenopathy, including KSHV‑associated multicentric Castleman disease, Hodgkin lymphoma, or non‑Hodgkin lymphoma.
What is being studied AITests the TINY nucleic acid assay to detect EBV and KSHV in lymph node and blood samples.
Who can join AIPeople hospitalized with a confirmed plasma cell disorder (examples: multiple myeloma, amyloidosis, MGUS, MGRS, POEMS and related conditions).
What is being studied AICollects clinical data and blood, bone marrow and urine samples over time.
Who can join AIAdults with HIV or other immunodeficiencies and cancer, viral-associated cancers (including Kaposi sarcoma), Castleman disease, or tumors linked to endogenous retroviruses.
What is being studied AICollects tumor and non-tumor samples for genetic and molecular analyses.
Who can join AIAdults (≥18) with HIV, KSHV or related viral infections/seropositivity, KSHV‑related lesions or cancers (e.g., Kaposi's sarcoma, PEL, MCD), or lymphomas.
What is being studied AICollects blood, bone marrow, tumor, and other tissue samples for research.
Who can join AIPeople diagnosed with monogenic or polygenic autoinflammatory diseases, including Behçet's disease, Still disease, PFAPA, Schnitzler, VEXAS, spondyloarthritis, Castleman disease, and non-infectious uveitis or scleritis.
What is being studied AICollects clinical, genetic, treatment, and outcome data in people with autoinflammatory diseases.
Who can join AIAdults (≥18) with a documented plasma cell disorder such as multiple myeloma, amyloidosis, MGUS, POEMS, Castleman's, plasma cell leukemia, light/heavy-chain deposition disease, or cryoglobulinemia.
What is being studied AICollects longitudinal geriatric-style assessments and optional blood samples (p16INK4a) from adults with plasma cell disorders.