September 2026 Research Update

At a glance

Kidney damage risk

AA amyloidosis was uncommon, but could severely affect kidneys.

Early warning sign

AA amyloidosis sometimes appeared before the autoinflammatory diagnosis.

Transplant and death

Kidney transplant and death were reported in the overall AA group.

Uncommon, serious kidney risk

This month added context that AA amyloidosis was uncommon overall, with few CAPS cases in the AA group. When it occurred, it could come before diagnosis and was often linked to serious kidney involvement.

Overview

This month, the main new information for CAPS came from a French referral-center review about AA amyloidosis, a protein build-up linked to long-term inflammation.

The key change is clearer context on how often AA amyloidosis showed up in a large group of inherited autoinflammatory diseases. In this dataset, AA amyloidosis was described as uncommon overall. Only a small number of people with CAPS were included among those with AA amyloidosis.

When AA amyloidosis did occur, it often came with serious kidney involvement. In the overall AA amyloidosis group, kidney transplant was reported in 46% of people during follow-up. Death during follow-up was reported in 26% of the group.

Another practical point is timing. AA amyloidosis was found before the underlying autoinflammatory disease diagnosis in 40% of cases. This pattern was reported especially in non-FMF diseases, a group that includes CAPS.

Research topics this month

Limitations

• This evidence came from a single national referral-center review, so it may not reflect typical care settings.
• Only a small number of CAPS patients with AA amyloidosis were included, limiting CAPS-specific conclusions.
• Reported transplant and death numbers apply to the overall AA amyloidosis group, not specifically to CAPS.

Important information

• This document summarizes recent research from PubMed-indexed publications using automated methods.
• It is intended for educational purposes and does not replace medical advice.
• Links to the original studies are provided via PubMed, where readers can explore abstracts and, when available, access full-text articles.
• Some studies may include additional details that were not accessible for this summary.
• Readers seeking more complete detail or context may find it helpful to review the original studies directly.

1. 1.El Moussaoui M, Savey L, Aloui-Belhocine HS, Boffa JJ, Delplanque M, Grandpeix-Guyodo C, Giurgea I, Cuisset L, Boursier G, Grateau G, Buob D, Georgin-Lavialle S. AA amyloidosis in the four historical monogenic autoinflammatory diseases: Clinical burden and insights from a retrospective referral-centre study. J Intern Med (2026). Open in new tab